CACNA1G overexpression induces spike-wave discharges

This paper demonstrates that overexpression of CACNA1G using a transgenic mouse model results in spike-wave discharges and absence seizures, indicating that enhancement of T-type calcium currents is sufficient for the generation of absence seizures.

The authors demonstrate that CACNA1G mediated currents are both necessary sufficient for the generation of absence seizures.  Genetic ablation of this gene actually makes mice resistent against spike-wave discharges when introduced into other mouse models.

Ingo

This 2009 blog post has been transferred to the EuroEPINOMICS blog from www.epilepsygenetics.net.

Please quote this blog (APA format) as

Helbig, I. CACNA1G overexpression induces spike-wave discharges. Retrieved [enter date], from http://www.euroepinomics.wordpress.com

One thought on “CACNA1G overexpression induces spike-wave discharges

  1. Pingback: CACNA2D2, the ducky mouse, and what it takes to be an epilepsy gene | Beyond the Ion Channel

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s